HiCANU is an add-on assembly tool to the popular long read Canu assembler. The assembler is still called Canu but has the added option to read PacBio HiFi reads using ‘-pacbio-hifi’. The main advantage of this tool is the ability to use the highly accurate and long HiFi reads for genome assembly. The algorithm implements homopolymer compression, overlap-based error correction, and aggressive false overlap filtering.
Sequence assembly
Nurk S, Walenz BP, Rhie A, Vollger MR, Logsdon GA, Grothe R, Miga KH, Eichler EE, Phillippy AM, Koren S "HiCanu: accurate assembly of segmental duplications, satellites, and allelic variants from high-fidelity long reads." Genome Res, 2020 https://doi.org/10.1101/gr.263566.120
PMID: 32801147
PMCID: None
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